Unknown

Dataset Information

0

Molecular evidence of SARS-CoV-2 in New York before the first pandemic wave.


ABSTRACT: Numerous reports document the spread of SARS-CoV-2, but there is limited information on its introduction before the identification of a local case. This may lead to incorrect assumptions when modeling viral origins and transmission. Here, we utilize a sample pooling strategy to screen for previously undetected SARS-CoV-2 in de-identified, respiratory pathogen-negative nasopharyngeal specimens from 3,040 patients across the Mount Sinai Health System in New York. The patients had been previously evaluated for respiratory symptoms or influenza-like illness during the first 10 weeks of 2020. We identify SARS-CoV-2 RNA from specimens collected as early as 25 January 2020, and complete SARS-CoV-2 genome sequences from multiple pools of samples collected between late February and early March, documenting an increase prior to the later surge. Our results provide evidence of sporadic SARS-CoV-2 infections a full month before both the first officially documented case and emergence of New York as a COVID-19 epicenter in March 2020.

SUBMITTER: Hernandez MM 

PROVIDER: S-EPMC8187428 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8136714 | biostudies-literature
| S-EPMC8604305 | biostudies-literature
| S-EPMC8156350 | biostudies-literature
2022-09-06 | GSE207923 | GEO
| S-EPMC8001481 | biostudies-literature
2024-01-26 | PXD046829 | Pride
| S-EPMC7572090 | biostudies-literature
| S-EPMC8360701 | biostudies-literature
2022-04-29 | E-MTAB-11240 | biostudies-arrayexpress
| S-EPMC8572359 | biostudies-literature