Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles.

ABSTRACT: The prevalence of neurological/neurodegenerative diseases, such as Alzheimer's disease is known to be increasing due to an aging population and is anticipated to further grow in the decades ahead. The treatment of brain diseases is challenging partly due to the inaccessibility of therapeutic agents to the brain. An increasingly important observation is that the physiology of the brain alters during many brain diseases, and aging adds even more to the complexity of the disease. There is a notion that the permeability of the blood-brain barrier (BBB) increases with aging or disease, however, the body has a defense mechanism that still retains the separation of the brain from harmful chemicals in the blood. This makes drug delivery to the diseased brain, even more challenging and complex task

SUBMITTER: Islam Y 

PROVIDER: S-EPMC8188209 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature