The relationship between antihypertensive medications and mood disorders: analysis of linked healthcare data for 1.8 million patients.

ABSTRACT:

Background

Recent work suggests that antihypertensive medications may be useful as repurposed treatments for mood disorders. Using large-scale linked healthcare data we investigated whether certain classes of antihypertensive, such as angiotensin antagonists (AAs) and calcium channel blockers, were associated with reduced risk of new-onset major depressive disorder (MDD) or bipolar disorder (BD).

Method

Two cohorts of patients treated with antihypertensives were identified from Scottish prescribing (2009-2016) and hospital admission (1981-2016) records. Eligibility for cohort membership was determined by a receipt of a minimum of four prescriptions for antihypertensives within a 12-month window. One treatment cohort (n = 538 730) included patients with no previous history of

SUBMITTER: Shaw RJ 

PROVIDER: S-EPMC8188528 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature