Ontology highlight
ABSTRACT:
SUBMITTER: Ji S
PROVIDER: S-EPMC8189146 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Ji Shuhan S Gumina Diane D McPeak Kathryn K Moldovan Radu R Post Miriam D MD Su Emily J EJ
Clinical science (London, England : 1979) 20210501 9
Pregnancies complicated by severe, early-onset fetal growth restriction with abnormal Doppler velocimetry (FGRadv) have a sparse villous vascular tree secondary to impaired angiogenesis. As endothelial cell (EC) and stromal matrix interactions are key regulators of angiogenesis, we investigated the role of placental stromal villous matrix on fetoplacental EC angiogenesis. We have developed a novel model of generating placental fibroblast (FB) cell-derived matrices (CDMs), allowing us to interrog ...[more]