Effect of Angiotensin System Inhibitors on Physical Performance in Older People - A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

Preclinical and observational data suggest that angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) may be able to improve physical performance in older people via direct and indirect effects on skeletal muscle. We aimed to summarize current evidence from randomised controlled trials in this area.

Design

Systematic review and meta-analysis.

Setting and participants

Randomized controlled trials enrolling older people, comparing ACEi or ARB to placebo, usual care or another antihypertensive agent, with outcome data on measures of physical performance.

Methods

We searched multiple electronic databases without language restriction between inception and the end of February 2020. Trials were excluded if the mean age of p

SUBMITTER: Caulfield L 

PROVIDER: S-EPMC8189253 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature