Ontology highlight
ABSTRACT:
SUBMITTER: Higdon LE
PROVIDER: S-EPMC8190404 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Higdon Lauren E LE Gustafson Claire E CE Ji Xuhuai X Sahoo Malaya K MK Pinsky Benjamin A BA Margulies Kenneth B KB Maecker Holden T HT Goronzy Jorg J Maltzman Jonathan S JS
Frontiers in immunology 20210527
Immune function is altered with increasing age. Infection with cytomegalovirus (CMV) accelerates age-related immunological changes resulting in expanded oligoclonal memory CD8 T cell populations with impaired proliferation, signaling, and cytokine production. As a consequence, elderly CMV seropositive (CMV<sup>+</sup>) individuals have increased mortality and impaired responses to other infections in comparison to seronegative (CMV<sup>-</sup>) individuals of the same age. CMV is also a signific ...[more]