Evaluation of ¹⁸F-AlF-NOTA-octreotide for imaging neuroendocrine neoplasms: comparison with ⁶⁸Ga-DOTATATE PET/CT.

ABSTRACT:

Objective

To evaluate the diagnostic efficacy of ¹⁸F-AlF-NOTA-octreotide (¹⁸F-OC) PET/CT compared with that of ⁶⁸Ga-DOTATATE PET/CT.

Materials and methods

Twenty patients (mean age: 52.65 years, range: 24-70 years) with biopsy-proven neuroendocrine neoplasms (NENs) were enrolled in this prospective study. We compared the biodistribution profiles in normal organs based on the maximum standard uptake value (SUV_max) and mean standard uptake value (SUV_mean), and uptake in NEN lesions by measuring the SUV_max on ¹⁸F-OC and ⁶⁸Ga-DOTATATE PET/CT images. The tumor-to-liver ratio (TLR) and tumor-to-spleen ratio were calculated by dividing the SUV_max of different tumor lesions by the SUV<

SUBMITTER: Hou J 

PROVIDER: S-EPMC8190415 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature