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Synthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction.

ABSTRACT: A concise and efficient cross-coupling synthetic strategy has been developed to construct 2-aryl-4H-thiochromen-4-one derivatives from 2-sulfinyl-thiochromones and arylboronic acids. This reaction proceeds via a catalyst system of Lewis acid and palladium(II) combined with XPhos as an optimal ligand in moderate to good yields. Besides, this flexible methodology provides a wide scope for the synthesis of different functionally substituted thiochromone scaffolds and can be further exploited to construct diverse thioflavone libraries for pharmaceutical research.

SUBMITTER: Li P

PROVIDER: S-EPMC8190924 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Asymmetric synthesis of quaternary aryl amino acid derivatives via a three-component aryne coupling reaction.

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On-surface synthesis of planar dendrimers via divergent cross-coupling reaction.

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Anti-Markovnikov hydroalkylation of allylic amine derivatives via a palladium-catalyzed reductive cross-coupling reaction.

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