Inconvenient relationship of haemoglobin A1c level with endothelial function in type 2 diabetes in a cross-sectional study.

ABSTRACT:

Objective

The aim of this study was to determine the relationship of haemoglobin A1c (HbA1c) level with flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) in patients with type 2 diabetes.

Design

Cross-sectional study.

Setting

22 university hospitals and affiliated clinics in Japan.

Participants

1215 patients with type 2 diabetes including 349 patients not taking antidiabetic drugs.

Measures

We evaluated FMD and HbA1c level. All patients were divided into four groups based on HbA1c level: <6.5%, 6.5%-6.9%, 7.0%-7.9% and ≥8.0%.

Results

An inverted U-shaped pattern of association between HbA1c level and FMD was observed at the peak of HbA1c of about 7%. FMD was significantly smaller in the HbA1c <6.5% group than in the Hb

SUBMITTER: Yamaji T 

PROVIDER: S-EPMC8191618 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature