Heritability of brain resilience to perturbation in humans.

ABSTRACT: Resilience is the capacity of complex systems to persist in the face of external perturbations and retain their functional properties and performance. In the present study, we investigated how individual variations in brain resilience, which might influence response to stress, aging and disease, are influenced by genetics and/or the environment, with potential implications for the implementation of resilience-boosting interventions. Resilience estimates were derived from in silico lesioning of either brain regions or functional connections constituting the connectome of healthy individuals belonging to two different large and unique datasets of twins, specifically: 463 individual twins from the Human Connectome Project and 453 individual twins from the Colorado Longitudinal Twin Study. As

SUBMITTER: Menardi A 

PROVIDER: S-EPMC8192441 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature