Structure and regulation of human phospholipase D.
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ABSTRACT:
SUBMITTER: Bowling FZ
PROVIDER: S-EPMC8193641 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Structure and regulation of human phospholipase D.
Bowling Forrest Z FZ Frohman Michael A MA Airola Michael V MV
Advances in biological regulation 20210103
Mammalian phospholipase D (PLD) generates phosphatidic acid, a dynamic lipid secondary messenger involved with a broad spectrum of cellular functions including but not limited to metabolism, migration, and exocytosis. As a promising pharmaceutical target, the biochemical properties of PLD have been well characterized. This has led to the recent crystal structures of human PLD1 and PLD2, the development of PLD specific pharmacological inhibitors, and the identification of cellular regulators of P ...[more]
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