Thyroid hormones modulate irisin concentrations in patients with recently onset hypothyroidism following total thyroidectomy.

ABSTRACT:

Purpose

Irisin is a newly discovered adipo-myokine known for having significant effects on body metabolism. Currently, there is a discussion regarding the relation between thyroid function and irisin concentration. This study was designed to evaluate the influential role of levothyroxine replacement therapy on circulating levels of irisin in patients with recently onset hypothyroidism following total thyroidectomy.

Methods

Circulating levels of thyroid hormones, irisin and other metabolic parameters, were assessed in 40 recently thyroidectomized patients (34 females, mean age 50.1 ± 15.2 years) at baseline (5-7 day after surgery) and after 2 months under replacement therapy with levothyroxine.

Results

At baseline, circulating levels of thyroid hormones were indicative

SUBMITTER: Bocale R 

PROVIDER: S-EPMC8195891 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature