Dataset Information

Joint effects of ambient air pollution and maternal smoking on neonatal adiposity and childhood BMI trajectories in the Healthy Start study.

ABSTRACT: Coexposure to air pollution and tobacco smoke may influence early-life growth, but few studies have investigated their joint effects. We examined the interaction between fetal exposure to maternal smoking and ozone (O₃) or fine particulate matter (PM_2.5) on birth weight, neonatal adiposity, and body mass index (BMI) trajectories through age 3 years.

Methods

Participants were 526 mother-child pairs, born ≥37 weeks. Cotinine was measured at ~27 weeks gestation. Whole pregnancy and trimester-specific O₃ and PM_2.5 were estimated via. inverse-distance weighted interpolation from stationary monitors. Neonatal adiposity (fat mass percentage) was measured via. air displacement plethysmography. Child weight and length/height were abstracted from medical records. Interaction was assessed by introducing cotinine (<31.5 vs. ≥31.5 ng/mL [indicating active smoking]), O₃/PM_2.5 (low [tertiles 1-2] vs. high [tertile 3]), and their product term in linear regression models for birth weight and neonatal adiposity and mixed-effects models for BMI trajectories.

Results

The rate of BMI growth among offspring jointly exposed to maternal smoking and high PM_2.5 (between 8.1 and 12.7 μg/m³) in the third trimester was more rapid than would be expected due to the individual exposures alone (0.8 kg/m² per square root year; 95% CI = 0.1, 1.5; P for interaction = 0.03). We did not detect interactions between maternal smoking and O₃ or PM_2.5 at any other time on birth weight, neonatal adiposity, or BMI trajectories.

Conclusions

Although PM_2.5 was generally below the EPA annual air quality standards of 12.0 μg/m³, exposure during the third trimester may influence BMI trajectories when combined with maternal smoking.

SUBMITTER: Moore BF

PROVIDER: S-EPMC8196098 | biostudies-literature |

REPOSITORIES: biostudies-literature

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