Joint effects of ambient air pollution and maternal smoking on neonatal adiposity and childhood BMI trajectories in the Healthy Start study.

ABSTRACT: Coexposure to air pollution and tobacco smoke may influence early-life growth, but few studies have investigated their joint effects. We examined the interaction between fetal exposure to maternal smoking and ozone (O₃) or fine particulate matter (PM_2.5) on birth weight, neonatal adiposity, and body mass index (BMI) trajectories through age 3 years.

Methods

Participants were 526 mother-child pairs, born ≥37 weeks. Cotinine was measured at ~27 weeks gestation. Whole pregnancy and trimester-specific O₃ and PM_2.5 were estimated via. inverse-distance weighted interpolation from stationary monitors. Neonatal adiposity (fat mass percentage) was measured via. air displacement plethysmography. Child weight and length/height were abstracted from me

SUBMITTER: Moore BF 

PROVIDER: S-EPMC8196098 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature