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Extracellular Vesicles as Potential Therapeutics for Inflammatory Diseases.

ABSTRACT: Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreover, engineered EVs are considered as promising nanoparticles to develop personalized therapeutic carriers. In this review, we highlight the role of EVs in various inflammatory diseases, the application of EV as anti-inflammatory therapeutics, and the current state of the art in EV engineering techniques.

SUBMITTER: Hwang HS

PROVIDER: S-EPMC8196952 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Extracellular Vesicles as Potential Therapeutics for Inflammatory Diseases.

Hwang Hee Sook HS Kim Hyosuk H Han Geonhee G Lee Jong Won JW Kim Kwangmeyung K Kwon Ick Chan IC Yang Yoosoo Y Kim Sun Hwa SH

International journal of molecular sciences 20210522 11

Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreo ...[more]

PMID: 34067503

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