Dataset Information

Noise Disturbance and Potential Hearing Loss Due to Exposure of Dental Equipment in Flemish Dentists.

ABSTRACT: Long-term exposure to occupational noise is often associated with noise-induced hearing loss (NIHL) among dentists. This study aims to investigate potential hearing loss (HL) and self-reported annoyance as a result of exposure to noise produced by contemporary dental equipment.

Methods

Three cohorts participated: 53 dentists with more than 5 years of service, 47 dentists with at most 5 years of service, and 53 pharmacists as controls, age and gender-matched to the first group. After the exclusion of one person, the hearing of 304 ears was screened with the Flemish version of the digit triplet in noise test (DTT). If screening failed, otoscopy and pure tone audiometry (PTA) were performed for both ears. Furthermore, general information, knowledge, exposure, annoyance, general health, and preventive measures were assessed with a custom-made questionnaire.

Results

NIHL did not occur significantly more often with dentists than with controls. However, dentists revealed a significantly higher annoyance (related to the noise from their equipment) and reported more complaints than the pharmacists. All three groups indicated lack of knowledge on hearing care.

Conclusions

While noise levels in contemporary dentistry are not harmful and do not induce NIHL, the sounds emitted by the devices are disturbing and affect mental health. This study calls for increased awareness of the consequences of sound exposure and stresses the need to monitor and protect the hearing of dentists regularly.

SUBMITTER: Dierickx M

PROVIDER: S-EPMC8197294 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Noise-induced hearing loss (NIHL) is a prevalent form of adult hearing impairment, characterized by oxidative damage to auditory sensory hair cells. Although certain dihydropyridines, the L-type calcium channel blockers, exhibit protective properties against such damage, the ability of third-generation dihydropryidines like lercanidipine to mitigate NIHL remains unclear.We utilized glucose oxidase (GO)-treated OC1 cell lines and cochlear explants to evaluate the protective influence of lercanidipine on hair cells. To further investigate its effectiveness, we exposed noise-stimulated mice in vivo and analyzed their hearing thresholds. Additionally, we assessed the antioxidative capabilities of lercanidipine by examining oxidation-related enzyme expression and levels of oxidative stress markers, including 3-nitrotyrosine (3NT) and 4-hydroxynonenal (4HNE). Our findings demonstrate that lercanidipine significantly reduces the adverse impacts of GO on both OC-1 cell viability (0.3 to 2.5 µM) and outer hair cell (OHC) survival in basal turn cochlear explants (7 µM). These results are associated with increased mRNA expression of antioxidant enzyme genes (HO-1, SOD1/2, and Txnrd1), along with decreased expression of oxidase genes (COX-2, iNOS). Crucially, lercanidipine administration prior to, and following, noise exposure effectively ameliorates NIHL, as evidenced by lowered hearing thresholds and preserved OHC populations in the basal turn, 14 days post-noise stimulation at 110 dB SPL. Moreover, our observations indicate that lercanidipine's antioxidative action persists even three days after simultaneous drug and noise treatments, based on 3-nitrotyrosine and 4-hydroxynonenal immunostaining in the basal turn. Based on these findings, we propose that lercanidipine has the capacity to alleviate NIHL and safeguard OHC survival in the basal turn, potentially via its antioxidative mechanism. These results suggest that lercanidipine holds promise as a clinically viable option for preventing NIHL in affected individuals.