Fine-Tuning Phylogenetic Alignment and Haplogrouping of mtDNA Sequences.
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ABSTRACT:
SUBMITTER: Dur A
PROVIDER: S-EPMC8198973 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Fine-Tuning Phylogenetic Alignment and Haplogrouping of mtDNA Sequences.
Dür Arne A Huber Nicole N Parson Walther W
International journal of molecular sciences 20210527 11
In this paper, we present a new algorithm for alignment and haplogroup estimation of mitochondrial DNA (mtDNA) sequences. Based on 26,011 vetted full mitogenome sequences, we refined the 5435 original haplogroup motifs of Phylotree Build 17 without changing the haplogroup nomenclature. We adapted 430 motifs (about 8%) and added 966 motifs for yet undetermined subclades. In summary, this led to an 18% increase of haplogroup defining motifs for full mitogenomes and a 30% increase for the mtDNA con ...[more]
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