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Non-Coding RNAs in Kidney Diseases: The Long and Short of Them.

ABSTRACT: Recent progress in genomic research has highlighted the genome to be much more transcribed than expected. The formerly so-called junk DNA encodes a miscellaneous group of largely unknown RNA transcripts, which contain the long non-coding RNAs (lncRNAs) family. lncRNAs are instrumental in gene regulation. Moreover, understanding their biological roles in the physiopathology of many diseases, including renal, is a new challenge. lncRNAs regulate the effects of microRNAs (miRNA) on mRNA expression. Understanding the complex crosstalk between lncRNA-miRNA-mRNA is one of the main challenges of modern molecular biology. This review aims to summarize the role of lncRNA on kidney diseases, the molecular mechanisms involved, and their function as emerging prognostic biomarkers for both acute and chronic kidney diseases. Finally, we will also outline new therapeutic opportunities to diminish renal injury by targeting lncRNA with antisense oligonucleotides.

SUBMITTER: Moreno JA 

PROVIDER: S-EPMC8200121 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Non-Coding RNAs in Kidney Diseases: The Long and Short of Them.

Moreno Juan Antonio JA   Hamza Eya E   Guerrero-Hue Melania M   Rayego-Mateos Sandra S   García-Caballero Cristina C   Vallejo-Mudarra Mercedes M   Metzinger Laurent L   Metzinger-Le Meuth Valérie V  

International journal of molecular sciences 20210604 11

Recent progress in genomic research has highlighted the genome to be much more transcribed than expected. The formerly so-called junk DNA encodes a miscellaneous group of largely unknown RNA transcripts, which contain the long non-coding RNAs (lncRNAs) family. lncRNAs are instrumental in gene regulation. Moreover, understanding their biological roles in the physiopathology of many diseases, including renal, is a new challenge. lncRNAs regulate the effects of microRNAs (miRNA) on mRNA expression.  ...[more]

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