Repeated influenza vaccination provides cumulative protection from distinct H3N2 viruses.

ABSTRACT:

Objectives

Current inactivated influenza vaccines provide suboptimal protection against antigenic drift, and repeated annual vaccinations shape antibody specificity but the effect on protection from infection is not well understood.

Methods

We studied the effects of cumulative and staggered vaccinations in mice to determine the effect of influenza vaccination on protection from infection and immune quality.

Results

We found that the timing of vaccination and antigenic change impacted the quality of immune responses. When mice received two different H3N2 strains (A/Hong Kong/4801/2014 and A/Singapore/INFIMH-16-0019/2016) by staggered timing of vaccination, there were higher H3HA antibody and B-cell memory responses than four cumulative vaccinations or when two vaccinat

SUBMITTER: Kavian N 

PROVIDER: S-EPMC8200319 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature