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Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong.

ABSTRACT:

Background

Prior to this report, variants of concern for SARS-CoV-2 were only detected from imported cases in Hong Kong.

Objective

Multiple cases of SARS-CoV-2 lineage B.1.351 have been identified in local community. We reported the phylogenetic relationship of these cases.

Study design

SARS-CoV-2 cases were screened for the key non-synonymous substitutions in spike protein by different assays. Preliminary positive cases were further tested by whole genome sequencing.

Results

From Dec 2020 to May 2021, 55 SARS-CoV-2 cases belonged to lineage B.1.351. Among them, eight genomes were clustered together, all of them were local cases with epidemiological link.

Conclusions

To track variants of SARS-CoV-2 and to allow early implementation of control measures, SARS-CoV-2 genomic surveillance must be consistently performed.

SUBMITTER: Tsang AKL

PROVIDER: S-EPMC8200330 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Publications

Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong.

Tsang Alan K L AKL Mak Gannon C K GCK Cheng Peter K C PKC Yip Peter C W PCW Ng Ken H L KHL Lam Edman T K ETK Chan Rickjason C W RCW Tsang Dominic N C DNC

Journal of clinical virology plus 20210614 3

<h4>Background</h4>Prior to this report, variants of concern for SARS-CoV-2 were only detected from imported cases in Hong Kong.<h4>Objective</h4>Multiple cases of SARS-CoV-2 lineage B.1.351 have been identified in local community. We reported the phylogenetic relationship of these cases.<h4>Study design</h4>SARS-CoV-2 cases were screened for the key non-synonymous substitutions in spike protein by different assays. Preliminary positive cases were further tested by whole genome sequencing.<h4>Re ...[more]

PMID: 35262015

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