Estimated GFR Variability and Risk of Cardiovascular Events and Mortality in SPRINT (Systolic Blood Pressure Intervention Trial).

ABSTRACT:

Rationale and objective

Although low estimated glomerular filtration rate (eGFR) is associated with cardiovascular disease (CVD) events and mortality, the clinical significance of variability in eGFR over time is uncertain. This study aimed to evaluate the associations between variability in eGFR and the risk of CVD events and all-cause mortality.

Study design

Longitudinal analysis of clinical trial participants.

Settings and participants

7,520 Systolic Blood Pressure Intervention Trial (SPRINT) participants ≥50 year of age with 1 or more CVD risk factors.

Predictors

eGFR variability, estimated by the coefficient of variation of eGFR assessments at the 6th, 12th, and 18-month study visits.

Outcomes

The SPRINT primary CVD composite outcome (myocardial inf

SUBMITTER: Malhotra R 

PROVIDER: S-EPMC8200370 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature