The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure.

ABSTRACT:

Background

Muscle wasting and unintentional weight loss (cachexia) have been associated with worse outcomes in heart failure (HF), but timely identification of these adverse phenomena is difficult. Spot urinary creatinine may be an easily accessible marker to assess muscle loss and cachexia. This study investigated the association of urinary creatinine with body composition changes and outcomes in patients with new-onset or worsening HF (WHF).

Methods

In BIOSTAT-CHF, baseline spot urinary creatinine measurements were available in 2315 patients with new-onset or WHF in an international cohort (index cohort) and a validation cohort of 1431 similar patients from Scotland.

Results

Median spot urinary creatinine concentrations were 5.2 [2.7-9.6] mmol/L in the index cohort.

SUBMITTER: Pandhi P 

PROVIDER: S-EPMC8200450 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature