Particulate Air Pollution and Risk of Cardiovascular Events Among Adults With a History of Stroke or Acute Myocardial Infarction.

ABSTRACT: Background Previous studies have found associations between fine particulate matter <2.5 µm in diameter (PM_2.5) and increased risk of cardiovascular disease (CVD) among populations with no CVD history. Less is understood about susceptibility of adults with a history of CVD and subsequent PM_2.5-related CVD events and whether current regulation levels for PM_2.5 are protective for this population. Methods and Results This retrospective cohort study included 96 582 Kaiser Permanente Northern California adults with a history of stroke or acute myocardial infarction. Outcome, covariate, and address data obtained from electronic health records were linked to time-varying 1-year mean PM_2.5 exposure estimates based on residential locations. Cox proportional hazard models estimated risks of stroke, acute myocardial infarction, and cardiovascular mortality associated with PM_2.5 exposure, adjusting for multiple covariates. Secondary analyses estimated risks below federal and state regulation levels (12 µg/m³ for 1-year mean PM_2.5). A 10-µg/m³ increase in 1-year mean PM_2.5 exposure was associated with an increase in risk of cardiovascular mortality (hazard ratio [HR], 1.20; 95% CI, 1.11-1.30), but no increase in risk of stroke or acute myocardial infarction. Analyses of <12 µg/m³ showed increased risk for CVD mortality (HR, 2.31; 95% CI, 1.96-2.71), stroke (HR, 1.41; 95% CI, 1.09-1.83]), and acute myocardial infarction (HR, 1.51; 95% CI, 1.21-1.89) per 10-µg/m³ increase in 1-year mean PM_2.5. Conclusions Adults with a history of CVD are susceptible to the effects of PM_2.5 exposure, particularly on CVD mortality. Increased risks observed at exposure levels <12 µg/m³ highlight that current PM_2.5 regulation levels may not be protective for this susceptible population.

SUBMITTER: Liao NS 

PROVIDER: S-EPMC8200700 | biostudies-literature |

REPOSITORIES: biostudies-literature