Expression status and prognostic value of the perilipin family of genes in breast cancer.

ABSTRACT:

Background

The Perilipin (PLIN) family of genes were previously shown to be involved in the formation and degradation of Lipid Droplets (LDs). In addition, they may play important roles in the development and progression of breast cancer. However, the prognostic value of PLIN family members in breast cancer patients remains unclear.

Methods

Mutations and copy number alterations of PLIN family genes in breast cancer were examined using the cBioportal for Cancer Genomics. In addition, the expression patterns of PLIN family genes were explored using the UCSC Xena online tool. Finally, the Kaplan-Meier Plotter was used to investigate the prognostic value of PLIN family genes in breast cancer.

Results

The findings revealed a low frequency of genetic alterations and amplifi

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8205812 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature