Neural correlates of RDoC-specific cognitive processes in a high-functional autistic patient: a statistically validated case report.

ABSTRACT: The level of functioning of individuals with autism spectrum disorder (ASD) varies widely. To better understand the neurobiological mechanism associated with high-functioning ASD, we studied the rare case of a female patient with an exceptional professional career in the highly competitive academic field of Mathematics. According to the Research Domain Criteria (RDoC) approach, which proposes to describe the basic dimensions of functioning by integrating different levels of information, we conducted four fMRI experiments targeting the (1) social processes domain (Theory of mind (ToM) and face matching), (2) positive valence domain (reward processing), and (3) cognitive domain (N-back). Patient's data were compared to data of 14 healthy controls (HC). Additionally, we assessed the subjectiv

SUBMITTER: Daedelow LS 

PROVIDER: S-EPMC8205905 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature