Dataset Information

Potential of tailored amorphous multiporous calcium silicate glass for pulp capping regenerative endodontics-A preliminary assessment.

ABSTRACT:

Introduction/objective

The tailored amorphous multi-porous (TAMP) material fabrication technology has led to a new class of bioactive materials possessing versatile characteristics. It has not been tested for dental applications. Thus, we aimed to assess its biocompatibility and ability to regenerate dental mineral tissue.

Methods

30CaO-70SiO₂ model TAMP discs were fabricated by a sol-gel method followed by in vitro biocompatibility testing with isolated human or mini-swine dental pulp stem cells (DPSCs). TAMP scaffolds were tested in vivo as a pulp exposure (pin-point, 1 mm, 2 mm, and entire pulp chamber roof) capping material in the molar teeth of mini-swine.

Results

The in vitro assays showed that DPSCs attached well onto the TAMP discs with comparable viability to those attached to culture plates. Pulp capping tests on mini-swine showed that after 4.5 months TAMP material was still present at the capping site, and mineral tissue (dentin bridge) had formed in all sizes of pulp exposure underneath the TAMP material.

Conclusions

TAMP calcium silicate is biocompatible with both human and swine DPSCs in vitro and with pulp in vivo, it may help regenerate the dentin bridge after pulp exposure.

SUBMITTER: Liu J

PROVIDER: S-EPMC8206035 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Publications

Potential of tailored amorphous multiporous calcium silicate glass for pulp capping regenerative endodontics-A preliminary assessment.

Liu Jie J Chen Chao-An CA Zhu Xiaofei X Morrow Brian R BR Thamma Ukrit U Kowal Tia J TJ Moawad Hassan M HM Falk Matthias M MM Jain Himanshu H Huang George T-J GT

Journal of dentistry 20210330

<h4>Introduction/objective</h4>The tailored amorphous multi-porous (TAMP) material fabrication technology has led to a new class of bioactive materials possessing versatile characteristics. It has not been tested for dental applications. Thus, we aimed to assess its biocompatibility and ability to regenerate dental mineral tissue.<h4>Methods</h4>30CaO-70SiO<sub>2</sub> model TAMP discs were fabricated by a sol-gel method followed by in vitro biocompatibility testing with isolated human or mini-s ...[more]

PMID: 33798640

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Dataset Information

Potential of tailored amorphous multiporous calcium silicate glass for pulp capping regenerative endodontics-A preliminary assessment.

Introduction/objective

Methods

Results

Conclusions

Publications

Potential of tailored amorphous multiporous calcium silicate glass for pulp capping regenerative endodontics-A preliminary assessment.

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