Extrusion-Based 3D Bioprinting of Gradients of Stiffness, Cell Density, and Immobilized Peptide Using Thermogelling Hydrogels.
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ABSTRACT:
SUBMITTER: Kuzucu M
PROVIDER: S-EPMC8207502 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Extrusion-Based 3D Bioprinting of Gradients of Stiffness, Cell Density, and Immobilized Peptide Using Thermogelling Hydrogels.
Kuzucu Merve M Vera Grace G Beaumont Marco M Fischer Sascha S Wei Pan P Shastri V Prasad VP Forget Aurelien A
ACS biomaterials science & engineering 20210510 6
To study biological processes <i>in vitro</i>, biomaterials-based engineering solutions to reproduce the gradients observed in tissues are necessary. We present a platform for the 3D bioprinting of functionally graded biomaterials based on carboxylated agarose, a bioink amendable by extrusion bioprinting. Using this bioink, objects with a gradient of stiffness and gradient of cell concentration were printed. Functionalization of carboxylated agarose with maleimide moieties that react in minutes ...[more]
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