Unknown

Dataset Information

0

Extrusion-Based 3D Bioprinting of Gradients of Stiffness, Cell Density, and Immobilized Peptide Using Thermogelling Hydrogels.


ABSTRACT: To study biological processes in vitro, biomaterials-based engineering solutions to reproduce the gradients observed in tissues are necessary. We present a platform for the 3D bioprinting of functionally graded biomaterials based on carboxylated agarose, a bioink amendable by extrusion bioprinting. Using this bioink, objects with a gradient of stiffness and gradient of cell concentration were printed. Functionalization of carboxylated agarose with maleimide moieties that react in minutes with a cysteine-terminated cell-adhesion peptide allowed us to print objects with a gradient of an immobilized peptide. This approach paves the way toward the development of tissue mimics with gradients.

SUBMITTER: Kuzucu M 

PROVIDER: S-EPMC8207502 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6941869 | biostudies-literature
| S-EPMC6165498 | biostudies-other
| S-EPMC4951698 | biostudies-other
| S-EPMC7854667 | biostudies-literature
| S-EPMC6066187 | biostudies-literature
| S-EPMC5826872 | biostudies-literature
| S-EPMC8548422 | biostudies-literature
| S-EPMC8287509 | biostudies-literature
| S-EPMC5837947 | biostudies-literature
| S-EPMC3694360 | biostudies-literature