One-Step Preparation of Nitrogen-Doped Graphene Quantum Dots With Anodic Electrochemiluminescence for Sensitive Detection of Hydrogen Peroxide and Glucose.

ABSTRACT: Simple and efficient synthesis of graphene quantum dots (GQDs) with anodic electrochemiluminescence (ECL) remains a great challenge. Herein, we present an anodic ECL-sensing platform based on nitrogen-doped GQDs (N-GQDs), which enables sensitive detection of hydrogen peroxide (H₂O₂) and glucose. N-GQDs are easily prepared using one-step molecular fusion between carbon precursor and a dopant in an alkaline hydrothermal process. The synthesis is simple, green, and has high production yield. The as-prepared N-GQDs exhibit a single graphene-layered structure, uniform size, and good crystalline. In the presence of H₂O₂, N-GQDs possess high anodic ECL activity owing to the functional hydrazide groups. With N-GQDs being ECL probes, sensitive detection of H₂O₂ in the range of 0.3-100.0 μM with a limit of detection or LOD of 63 nM is achieved. As the oxidation of glucose catalyzed by glucose oxidase (GOx) produces H₂O₂, sensitive detection of glucose is also realized in the range of 0.7-90.0 μM (LOD of 96 nM).

SUBMITTER: Yanyan Z 

PROVIDER: S-EPMC8207508 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature