The expression of miRNA-152-3p and miRNA-185 in tumor tissues versus margin tissues of patients with chemo-treated breast cancer.

ABSTRACT:

Objective

Breast cancer (BC) is the most significant and lethal type of cancer in women. Although there are many newly develop chemotherapy drugs for patients with BC treating at various stages, drug resistance is the most important obstacle in their effectiveness for BC treatment. On the other hand, microRNAs are considered key regulators of genes involved in carcinogenesis and chemoresistance in cancers. The purpose of this study was to evaluate the role of miR-152-3p and miR-185 in intrinsic chemoresistance and proliferation of BC. In addition, the potential role of these miRNAs during chemoresistance was evaluated through possible signaling pathways.

Results

Here, miR-152-3p was significantly downregulated in tumor tissues compared to the corresponding margin tissues in

SUBMITTER: Safi A 

PROVIDER: S-EPMC8207775 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature