A distributed saccade-associated network encodes high velocity conjugate and monocular eye movements in the zebrafish hindbrain.

ABSTRACT: Saccades are rapid eye movements that redirect gaze. Their magnitudes and directions are tightly controlled by the oculomotor system, which is capable of generating conjugate, monocular, convergent and divergent saccades. Recent studies suggest a mainly monocular control of saccades in mammals, although the development of binocular control and the interaction of different functional populations is less well understood. For zebrafish, a well-established model in sensorimotor research, the nature of binocular control in this key oculomotor behavior is unknown. Here, we use the optokinetic response and calcium imaging to characterize how the developing zebrafish oculomotor system encodes the diverse repertoire of saccades. We find that neurons with phasic saccade-associated activity (putative

SUBMITTER: Leyden C 

PROVIDER: S-EPMC8209155 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature