Ontology highlight
ABSTRACT:
SUBMITTER: Shiimori M
PROVIDER: S-EPMC8209278 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Shiimori Masami M Ichida Yu Y Nukiwa Ryota R Sakuma Toshie T Abe Haruka H Kajitani Rei R Fujino Yuji Y Kikuchi Akira A Kawamura Takeshi T Kodama Tatsuhiko T Toyooka Shinichi S Shirahige Katsuhiko K Schotta Gunnar G Kuba Keiji K Itoh Takehiko T Imai Yumiko Y
iScience 20210529 6
The spatial organization of chromatin is known to be highly dynamic in response to environmental stress. However, it remains unknown how chromatin dynamics contributes to or modulates disease pathogenesis. Here, we show that upon influenza virus infection, the H4K20me3 methyltransferase Suv4-20h2 binds the viral protein NP, which results in the inactivation of Suv4-20h2 and the dissociation of cohesin from Suv4-20h2. Inactivation of Suv4-20h2 by viral infection or genetic deletion allows the for ...[more]