Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Q
PROVIDER: S-EPMC8210618 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Zhou Quan Q van den Berg Nynke S NS Rosenthal Eben L EL Iv Michael M Zhang Michael M Vega Leonel Johana C M JCM Walters Shannon S Nishio Naoki N Granucci Monica M Raymundo Roan R Yi Grace G Vogel Hannes H Cayrol Romain R Lee Yu-Jin YJ Lu Guolan G Hom Marisa M Kang Wenying W Hayden Gephart Melanie M Recht Larry L Nagpal Seema S Thomas Reena R Patel Chirag C Grant Gerald A GA Li Gordon G
Theranostics 20210521 15
<b>Rationale</b>: First-line therapy for high-grade gliomas (HGGs) includes maximal safe surgical resection. The extent of resection predicts overall survival, but current neuroimaging approaches lack tumor specificity. The epidermal growth factor receptor (EGFR) is a highly expressed HGG biomarker. We evaluated the safety and feasibility of an anti-EGFR antibody, panitumuab-IRDye800, at subtherapeutic doses as an imaging agent for HGG. <b>Methods</b>: Eleven patients with contrast-enhancing HGG ...[more]