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Adaptive compounding speckle-noise-reduction filter for optical coherence tomography images.

ABSTRACT: Speckle noise limits the diagnostic capabilities of optical coherence tomography (OCT) images, causing both a reduction in contrast and a less accurate assessment of the microstructural morphology of the tissue. We present a speckle-noise reduction method for OCT volumes that exploits the advantages of adaptive-noise wavelet thresholding with a wavelet compounding method applied to several frames acquired from consecutive positions. The method takes advantage of the wavelet representation of the speckle statistics, calculated properly from a homogeneous sample or a region of the noisy volume. The proposed method was first compared quantitatively with different state-of-the-art approaches by being applied to three different clinical dermatological OCT volumes with three different OCT settings. The method was also applied to a public retinal spectral-domain OCT dataset to demonstrate its applicability to different imaging modalities. The results based on four different metrics demonstrate that the proposed method achieved the best performance among the tested techniques in suppressing noise and preserving structural information. The proposed OCT denoising technique has the potential to adapt to different image OCT settings and noise environments and to improve image quality prior to clinical diagnosis based on visual assessment.

SUBMITTER: Gomez-Valverde JJ

PROVIDER: S-EPMC8211087 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Adaptive compounding speckle-noise-reduction filter for optical coherence tomography images.

Gómez-Valverde Juan J JJ Sinz Christoph C Rank Elisabet A EA Chen Zhe Z Santos Andrés A Drexler Wolfgang W Ledesma-Carbayo María J MJ

Journal of biomedical optics 20210601 6

<h4>Significance</h4>Speckle noise limits the diagnostic capabilities of optical coherence tomography (OCT) images, causing both a reduction in contrast and a less accurate assessment of the microstructural morphology of the tissue.<h4>Aim</h4>We present a speckle-noise reduction method for OCT volumes that exploits the advantages of adaptive-noise wavelet thresholding with a wavelet compounding method applied to several frames acquired from consecutive positions. The method takes advantage of t ...[more]

PMID: 34142472

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Project description:Adaptive optics optical coherence tomography (AO-OCT) technology enables non-invasive, high-resolution three-dimensional (3D) imaging of the retina and promises earlier detection of ocular disease. However, AO-OCT data are corrupted by eye-movement artifacts that must be removed in post-processing, a process rendered time-consuming by the immense quantity of data. To efficiently remove eye-movement artifacts at the level of individual A-lines, including those present in any individual reference volume. We developed a registration method that cascades (1) a 3D B-scan registration algorithm with (2) a global A-line registration algorithm for correcting torsional eye movements and image scaling and generating global motion-free coordinates. The first algorithm corrects 3D translational eye movements to a single reference volume, accelerated using parallel computing. The second algorithm combines outputs of multiple runs of the first algorithm using different reference volumes followed by an affine transformation, permitting registration of all images to a global coordinate system at the level of individual A-lines. The 3D B-scan algorithm estimates and corrects 3D translational motions with high registration accuracy and robustness, even for volumes containing microsaccades. Averaging registered volumes improves our image quality metrics up to 22 dB. Implementation in CUDA™ on a graphics processing unit registers a 512 × 512 × 512 volume in only 10.6 s, 150 times faster than MATLAB™ on a central processing unit. The global A-line algorithm minimizes image distortion, improves regularity of the cone photoreceptor mosaic, and supports enhanced visualization of low-contrast retinal cellular features. Averaging registered volumes improves our image quality up to 9.4 dB. It also permits extending the imaging field of view (∼2.1 × ) and depth of focus (∼5.6 × ) beyond what is attainable with single-reference registration. We can efficiently correct eye motion in all 3D at the level of individual A-lines using a global coordinate system.

Dataset Information

Adaptive compounding speckle-noise-reduction filter for optical coherence tomography images.

Publications

Adaptive compounding speckle-noise-reduction filter for optical coherence tomography images.

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