An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles.

ABSTRACT: Recent results comparing the temporal program of genome replication of yeast species belonging to the Lachancea clade support the scenario that the evolution of the replication timing program could be mainly driven by correlated acquisition and loss events of active replication origins. Using these results as a benchmark, we develop an evolutionary model defined as birth-death process for replication origins and use it to identify the evolutionary biases that shape the replication timing profiles. Comparing different evolutionary models with data, we find that replication origin birth and death events are mainly driven by two evolutionary pressures, the first imposes that events leading to higher double-stall probability of replication forks are penalized, while the second makes les

SUBMITTER: Droghetti R 

PROVIDER: S-EPMC8213407 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature