Ontology highlight
ABSTRACT:
SUBMITTER: Lentini G
PROVIDER: S-EPMC8213820 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Lentini Gaëlle G Ben Chaabene Rouaa R Vadas Oscar O Ramakrishnan Chandra C Mukherjee Budhaditya B Mehta Ved V Lunghi Matteo M Grossmann Jonas J Maco Bohumil B Visentin Rémy R Hehl Adrian B AB Korkhov Volodymyr M VM Soldati-Favre Dominique D
Nature communications 20210618 1
Active host cell invasion by the obligate intracellular apicomplexan parasites relies on the formation of a moving junction, which connects parasite and host cell plasma membranes during entry. Invading Toxoplasma gondii tachyzoites secrete their rhoptry content and insert a complex of RON proteins on the cytoplasmic side of the host cell membrane providing an anchor to which the parasite tethers. Here we show that a rhoptry-resident kinase RON13 is a key virulence factor that plays a crucial ro ...[more]