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City footprints and SDGs provide untapped potential for assessing city sustainability.

ABSTRACT: Cities are recognised as central to determining the sustainability of human development. However, assessment concepts that are able to ascertain whether or not a city is sustainable are only just emerging. Here we review literature since the Sustainable Development Goals (SDGs) were agreed in 2015 and identify three strands of scientific inquiry and practice in assessing city sustainability. We find that further integration is needed. SDG monitoring and assessment of cities should take advantage of both consumption-based (footprint) accounting and benchmarking against planetary boundaries and social thresholds in order to achieve greater relevance for designing sustainable cities and urban lifestyles.

SUBMITTER: Wiedmann T

PROVIDER: S-EPMC8213854 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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City footprints and SDGs provide untapped potential for assessing city sustainability.

Wiedmann Thomas T Allen Cameron C

Nature communications 20210618 1

Cities are recognised as central to determining the sustainability of human development. However, assessment concepts that are able to ascertain whether or not a city is sustainable are only just emerging. Here we review literature since the Sustainable Development Goals (SDGs) were agreed in 2015 and identify three strands of scientific inquiry and practice in assessing city sustainability. We find that further integration is needed. SDG monitoring and assessment of cities should take advantage ...[more]

PMID: 34145276

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Project description:Since its initial discovery almost three decades ago, the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) has been shown to regulate a host of downstream transcriptional responses and play a critical role in preventing or promoting disease progression depending on the context. Critically, while the importance of proper nuclear factor erythroid 2-related factor 2 function has been demonstrated across a variety of pathological settings, the ability to progress NRF2-targeted therapeutics to clinic has remained frustratingly elusive. This is particularly true in the case of age-related pathologies, where nuclear factor erythroid 2-related factor 2 is a well-established mitigator of many of the observed pathogenic effects, yet options to target this pathway remain limited. Along these lines, loss of nuclear factor erythroid 2-related factor 2 function has clearly been shown to enhance neuropathological outcomes, with enhancing nuclear factor erythroid 2-related factor 2 pathway activation to prevent neurodegenerative/neurological disease progression continuing to be an active area of interest. One critical obstacle in generating successful therapeutics for brain-related pathologies is the ability of the compound to cross the blood brain barrier (BBB), which has also hampered the implementation of several promising nuclear factor erythroid 2-related factor 2 inducers. Another limitation is that many nuclear factor erythroid 2-related factor 2 activators have undesirable off-target effects due to their electrophilic nature. Despite these constraints, the field has continued to evolve, and several viable means of targeting nuclear factor erythroid 2-related factor 2 in a neuropathological context have emerged. In this perspective, we will briefly discuss the key findings and promising therapeutic options that have been discovered to date, as well as highlight emerging areas of NRF2-neurodegeneration research that provide hope for successfully targeting this pathway in the future.

Dataset Information

City footprints and SDGs provide untapped potential for assessing city sustainability.

Publications

City footprints and SDGs provide untapped potential for assessing city sustainability.

Similar Datasets

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