Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictors.

ABSTRACT:

Background/purpose

The association between dysregulated innate immune responses seen in Kawasaki disease (KD) with predisposition to Kawasaki-like multisystem inflammatory syndrome in children (MIS-C) remains unclear. We aimed to compare the innate immunity transcriptome signature between COVID-19 and KD, and to analyze the interactions of these molecules with genes known to predispose to KD.

Methods

Transcriptome datasets of COVID-19 and KD cohorts (E-MTAB-9357, GSE-63881, GSE-68004) were downloaded from ArrayExpress for innate immune response analyses. Network analysis was used to determine enriched pathways of interactions.

Results

Upregulations of IRAK4, IFI16, STING, STAT3, PYCARD, CASP1, IFNAR1 and CD14 genes were observed in blood cells of acute SARS-CoV-2 infe

SUBMITTER: Yang CA 

PROVIDER: S-EPMC8214167 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature