Mitochondrial Dynamics Related Genes -MFN1, MFN2 and DRP1 Polymorphisms are Associated with Risk of Lung Cancer.

ABSTRACT:

Purpose

This study aimed to evaluate the associations between mitochondrial dynamics related genes -MFN1, MFN2 and DRP1 polymorphisms and risk of lung cancer.

Methods

Six polymorphisms of MFN1, MFN2 and DRP1 were genotyped in 600 cases and 600 controls using a MassARRAY platform.

Results

The MFN1 rs13098637-C and DRP1 rs879255689-A alleles were associated with an increased risk of lung cancer (p _rs13098637=0.004, p _rs879255689=0.005), while MFN2 rs4240897-A and rs2236058-G were related to a decreased risk of disease (p<0.001). The rs13098637-TC/CC and rs879255689-GA/AA were determined as risk genotypes for lung cancer (p _rs13098637=0.014, p _rs87925

SUBMITTER: Liang X 

PROVIDER: S-EPMC8214204 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature