Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin.

ABSTRACT: Aldosterone is the major mineralocorticoid in the human body controlling blood pressure and salt homeostasis. Overproduction of aldosterone leads to primary aldosteronism, which is the most common form of secondary hypertension with limited treatment options. Production of aldosterone by cytochrome P450 11B2 (CYP11B2, aldosterone synthase) requires two reduction events with the electrons delivered by the iron/sulfur protein adrenodoxin. Very limited information is available about the structural and functional basis of adrenodoxin/CYP11B2 interaction, which impedes the development of new treatment options for primary aldosteronism. A systematic study was carried out to determine if adrenodoxin interaction with CYP11B2 might also have an allosteric component in addition to electron transfer.

SUBMITTER: Brixius-Anderko S 

PROVIDER: S-EPMC8215293 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature