Ontology highlight
ABSTRACT:
SUBMITTER: Zhuang Y
PROVIDER: S-EPMC8215686 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Zhuang Youwen Y Xu Peiyu P Mao Chunyou C Wang Lei L Krumm Brian B Zhou X Edward XE Huang Sijie S Liu Heng H Cheng Xi X Huang Xi-Ping XP Shen Dan-Dan DD Xu Tinghai T Liu Yong-Feng YF Wang Yue Y Guo Jia J Jiang Yi Y Jiang Hualiang H Melcher Karsten K Roth Bryan L BL Zhang Yan Y Zhang Cheng C Xu H Eric HE
Cell 20210210 4
The D1- and D2-dopamine receptors (D1R and D2R), which signal through G<sub>s</sub> and G<sub>i</sub>, respectively, represent the principal stimulatory and inhibitory dopamine receptors in the central nervous system. D1R and D2R also represent the main therapeutic targets for Parkinson's disease, schizophrenia, and many other neuropsychiatric disorders, and insight into their signaling is essential for understanding both therapeutic and side effects of dopaminergic drugs. Here, we report four c ...[more]