Pharmacogenomic landscape of COVID-19 therapies from Indian population genomes.
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ABSTRACT:
SUBMITTER: Sahana S
PROVIDER: S-EPMC8216321 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
Pharmacogenomic landscape of COVID-19 therapies from Indian population genomes.
Sahana S S Sivadas Ambily A Mangla Mohit M Jain Abhinav A Bhoyar Rahul C RC Pandhare Kavita K Mishra Anushree A Sharma Disha D Imran Mohamed M Senthivel Vigneshwar V Divakar Mohit Kumar MK Rophina Mercy M Jolly Bani B Batra Arushi A Sharma Sumit S Siwach Sanjay S Jadhao Arun G AG Palande Nikhil V NV Jha Ganga Nath GN Ashrafi Nishat N Mishra Prashant Kumar PK Vidhya A K AK Jain Suman S Dash Debasis D Kumar Nachimuthu Senthil NS Vanlallawma Andrew A Sarma Ranjan Jyoti RJ Chhakchhuak Lalchhandama L Kalyanaraman Shantaraman S Mahadevan Radha R Kandasamy Sunitha S Devi Pabitha P Rajagopal Raskin Erusan RE Ramya J Ezhil JE Devi P Nirmala PN Bajaj Anjali A Gupta Vishu V Mathew Samatha S Goswami Sangam S Prakash Savinitha S Joshi Kandarp K Kumla Meya M Sreedevi S S Gajjar Devarshi D Soraisham Ronibala R Yadav Rohit R Devi Yumnam Silla YS Gupta Aayush A Mukerji Mitali M Ramalingam Sivaprakash S Binukumar B K BK Sivasubbu Sridhar S Scaria Vinod V
Pharmacogenomics 20210618 10
<b>Aim:</b> Numerous drugs are being widely prescribed for COVID-19 treatment without any direct evidence for the drug safety/efficacy in patients across diverse ethnic populations. <b>Materials & methods:</b> We analyzed whole genomes of 1029 Indian individuals (IndiGen) to understand the extent of drug-gene (pharmacogenetic), drug-drug and drug-drug-gene interactions associated with COVID-19 therapy in the Indian population. <b>Results:</b> We identified 30 clinically significant pharmacogenet ...[more]
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