The Application and Development of Deep Learning in Radiotherapy: A Systematic Review.
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ABSTRACT:
SUBMITTER: Huang D
PROVIDER: S-EPMC8216350 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Covid-19 is now one of the most incredibly intense and severe illnesses of the twentieth century. Covid-19 has already endangered the lives of millions of people worldwide due to its acute pulmonary effects. Image-based diagnostic techniques like X-ray, CT, and ultrasound are commonly employed to get a quick and reliable clinical condition. Covid-19 identification out of such clinical scans is exceedingly time-consuming, labor-intensive, and susceptible to silly intervention. As a result, radiography imaging approaches using Deep Learning (DL) are consistently employed to achieve great results. Various artificial intelligence-based systems have been developed for the early prediction of coronavirus using radiography pictures. Specific DL methods such as CNN and RNN noticeably extract extremely critical characteristics, primarily in diagnostic imaging. Recent coronavirus studies have used these techniques to utilize radiography image scans significantly. The disease, as well as the present pandemic, was studied using public and private data. A total of 64 pre-trained and custom DL models concerning imaging modality as taxonomies are selected from the studied articles. The constraints relevant to DL-based techniques are the sample selection, network architecture, training with minimal annotated database, and security issues. This includes evaluating causal agents, pathophysiology, immunological reactions, and epidemiological illness. DL-based Covid-19 detection systems are the key focus of this review article. Covid-19 work is intended to be accelerated as a result of this study.
| S-EPMC9483290 | biostudies-literature
Project description:Subtle differences in a patient's genetics and physiology may alter radiotherapy (RT) treatment responses, motivating the need for a more personalized treatment plan. Accordingly, we have developed a novel quantum deep reinforcement learning (qDRL) framework for clinical decision support that can estimate an individual patient's dose response mid-treatment and recommend an optimal dose adjustment. Our framework considers patients' specific information including biological, physical, genetic, clinical, and dosimetric factors. Recognizing that physicians must make decisions amidst uncertainty in RT treatment outcomes, we employed indeterministic quantum states to represent human decision making in a real-life scenario. We paired quantum decision states with a model-based deep q-learning algorithm to optimize the clinical decision-making process in RT. We trained our proposed qDRL framework on an institutional dataset of 67 stage III non-small cell lung cancer (NSCLC) patients treated on prospective adaptive protocols and independently validated our framework in an external multi-institutional dataset of 174 NSCLC patients. For a comprehensive evaluation, we compared three frameworks: DRL, qDRL trained in a Qiskit quantum computing simulator, and qDRL trained in an IBM quantum computer. Two metrics were considered to evaluate our framework: (1) similarity score, defined as the root mean square error between retrospective clinical decisions and the AI recommendations, and (2) self-evaluation scheme that compares retrospective clinical decisions and AI recommendations based on the improvement in the observed clinical outcomes. Our analysis shows that our framework, which takes into consideration individual patient dose response in its decision-making, can potentially improve clinical RT decision-making by at least about 10% compared to unaided clinical practice. Further validation of our novel quantitative approach in a prospective study will provide a necessary framework for improving the standard of care in personalized RT.
| S-EPMC8651664 | biostudies-literature
Project description:BackgroundOral cancer is a life-threatening malignancy, which affects the survival rate and quality of life of patients. The aim of this systematic review was to review deep learning (DL) studies in the diagnosis and prognostic prediction of oral cancer.MethodsThis systematic review was conducted following the PRISMA guidelines. Databases (Medline via PubMed, Google Scholar, Scopus) were searched for relevant studies, from January 2000 to June 2023.ResultsFifty-four qualified for inclusion, including diagnostic (n = 51), and prognostic prediction (n = 3). Thirteen studies showed a low risk of biases in all domains, and 40 studies low risk for concerns regarding applicability. The performance of DL models was reported of the accuracy of 85.0-100%, F1-score of 79.31 - 89.0%, Dice coefficient index of 76.0 - 96.3% and Concordance index of 0.78-0.95 for classification, object detection, segmentation, and prognostic prediction, respectively. The pooled diagnostic odds ratios were 2549.08 (95% CI 410.77-4687.39) for classification studies.ConclusionsThe number of DL studies in oral cancer is increasing, with a diverse type of architectures. The reported accuracy showed promising DL performance in studies of oral cancer and appeared to have potential utility in improving informed clinical decision-making of oral cancer.
| S-EPMC10859022 | biostudies-literature
Project description:Due to the chaotic nature of soccer, the predictive statistical models have become in a current challenge to decision-making based on scientific evidence. The aim of the present study was to systematically identify original studies that applied machine learning (ML) to soccer data, highlighting current possibilities in ML and future applications. A systematic review of PubMed, SPORTDiscus, and FECYT (Web of Sciences, CCC, DIIDW, KJD, MEDLINE, RSCI, and SCIELO) was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. From the 145 studies initially identified, 32 were fully reviewed, and their outcome measures were extracted and analyzed. In summary, all articles were clustered into three groups: injury (n = 7); performance (n = 21), which was classified in match/league outcomes forecasting, physical/physiological forecasting, and technical/tactical forecasting; and the last group was about talent forecasting (n = 5). The development of technology, and subsequently the large amount of data available, has become ML in an important strategy to help team staff members in decision-making predicting dose-response relationship reducing the chaotic nature of this team sport. However, since ML models depend upon the amount of dataset, further studies should analyze the amount of data input needed make to a relevant predictive attempt which makes accurate predicting available.
| S-EPMC9806754 | biostudies-literature
Project description:Background and purposeTreatment planning of radiotherapy is a time-consuming and planner dependent process that can be automated by dose prediction models. The purpose of this study was to evaluate the performance of two machine learning models for breast cancer radiotherapy before possible clinical implementation.Materials and methodsAn in-house developed model, based on U-net architecture, and a contextual atlas regression forest (cARF) model integrated in the treatment planning software were trained. Obtained dose distributions were mimicked to create clinically deliverable plans. For training and validation, 90 patients were used, 15 patients were used for testing. Treatment plans were scored on predefined evaluation criteria and percent errors with respect to clinical dose were calculated for doses to planning target volume (PTV) and organs at risk (OARs).ResultsThe U-net plans before mimicking met all criteria for all patients, both models failed one evaluation criterion in three patients after mimicking. No significant differences (p < 0.05) were found between clinical and predicted U-net plans before mimicking. Doses to OARs in plans of both models differed significantly from clinical plans, but no clinically relevant differences were found. After mimicking, both models had a mean percent error within 1.5% for the average dose to PTV and OARs. The mean errors for maximum doses were higher, within 6.6%.ConclusionsDifferences between predicted doses to OARs of the models were small when compared to clinical plans, and not found to be clinically relevant. Both models show potential in automated treatment planning for breast cancer.
| S-EPMC8058017 | biostudies-literature
Project description: Not available
| S-EPMC9911394 | biostudies-literature
Project description:ObjectiveMulti-modal functional magnetic resonance imaging has been widely used for brain research. Conventional data-fusion methods cannot capture complex relationship (e.g., nonlinear predictive relationship) between multiple data. This paper aims to develop a neural network framework to extract phenotype related cross-data relationships and use it to study the brain development.MethodsWe propose a novel method, deep collaborative learning (DCL), to address the limitation of existing methods. DCL first uses a deep network to represent original data and then seeks their correlations, while also linking the data representation with phenotypical information.ResultsWe studied the difference of functional connectivity (FCs) between different age groups and also use FCs as a fingerprint to predict cognitive abilities. Our experiments demonstrated higher accuracy of using DCL over other conventional models when classifying populations of different ages and cognitive scores. Moreover, DCL revealed that brain connections became stronger at adolescence stage. Furthermore, DCL detected strong correlations between default mode network and other networks which were overlooked by linear canonical correlation analysis, demonstrating DCL's ability of detecting nonlinear correlations.ConclusionThe results verified the superiority of DCL over conventional data-fusion methods. In addition, the stronger brain connection demonstrated the importance of adolescence stage for brain development.SignificanceDCL can better combine complex correlations between multiple data sets in addition to their fitting to phenotypes, with the potential to overcome the limitations of several current data-fusion models.
| S-EPMC8177041 | biostudies-literature
Project description:Climate change represents one of the most critical threats to biodiversity with far-reaching consequences for species interactions, the functioning of ecosystems, or the assembly of biotic communities. Plant phenology research has gained increasing attention as the timing of periodic events in plants is strongly affected by seasonal and interannual climate variation. Recent technological development allowed us to gather invaluable data at a variety of spatial and ecological scales. The feasibility of phenological monitoring today and in the future depends heavily on developing tools capable of efficiently analyzing these enormous amounts of data. Deep Neural Networks learn representations from data with impressive accuracy and lead to significant breakthroughs in, e.g., image processing. This article is the first systematic literature review aiming to thoroughly analyze all primary studies on deep learning approaches in plant phenology research. In a multi-stage process, we selected 24 peer-reviewed studies published in the last five years (2016-2021). After carefully analyzing these studies, we describe the applied methods categorized according to the studied phenological stages, vegetation type, spatial scale, data acquisition- and deep learning methods. Furthermore, we identify and discuss research trends and highlight promising future directions. We present a systematic overview of previously applied methods on different tasks that can guide this emerging complex research field.
| S-EPMC8969581 | biostudies-literature
Project description:ObjectivesDeep learning (DL) has been increasingly employed for automated landmark detection, e.g., for cephalometric purposes. We performed a systematic review and meta-analysis to assess the accuracy and underlying evidence for DL for cephalometric landmark detection on 2-D and 3-D radiographs.MethodsDiagnostic accuracy studies published in 2015-2020 in Medline/Embase/IEEE/arXiv and employing DL for cephalometric landmark detection were identified and extracted by two independent reviewers. Random-effects meta-analysis, subgroup, and meta-regression were performed, and study quality was assessed using QUADAS-2. The review was registered (PROSPERO no. 227498).DataFrom 321 identified records, 19 studies (published 2017-2020), all employing convolutional neural networks, mainly on 2-D lateral radiographs (n=15), using data from publicly available datasets (n=12) and testing the detection of a mean of 30 (SD: 25; range.: 7-93) landmarks, were included. The reference test was established by two experts (n=11), 1 expert (n=4), 3 experts (n=3), and a set of annotators (n=1). Risk of bias was high, and applicability concerns were detected for most studies, mainly regarding the data selection and reference test conduct. Landmark prediction error centered around a 2-mm error threshold (mean; 95% confidence interval: (-0.581; 95 CI: -1.264 to 0.102 mm)). The proportion of landmarks detected within this 2-mm threshold was 0.799 (0.770 to 0.824).ConclusionsDL shows relatively high accuracy for detecting landmarks on cephalometric imagery. The overall body of evidence is consistent but suffers from high risk of bias. Demonstrating robustness and generalizability of DL for landmark detection is needed.Clinical significanceExisting DL models show consistent and largely high accuracy for automated detection of cephalometric landmarks. The majority of studies so far focused on 2-D imagery; data on 3-D imagery are sparse, but promising. Future studies should focus on demonstrating generalizability, robustness, and clinical usefulness of DL for this objective.
| S-EPMC8310492 | biostudies-literature
Project description:Malignant brain tumors pose a substantial burden on morbidity and mortality. As clinical data collection improves, along with the capacity to analyze it, novel predictive clinical tools may improve prognosis prediction. Deep learning (DL) holds promise for integrating clinical data of various modalities. A systematic review of the DL-based prognostication of gliomas was performed using the Embase (Elsevier), PubMed MEDLINE (National library of Medicine), and Scopus (Elsevier) databases, in accordance with PRISMA guidelines. All included studies focused on the prognostication of gliomas, and predicted overall survival (13 studies, 81%), overall survival as well as genotype (2 studies, 12.5%), and response to immunotherapy (1 study, 6.2%). Multimodal analyses were varied, with 6 studies (37.5%) combining MRI with clinical data; 6 studies (37.5%) integrating MRI with histologic, clinical, and biomarker data; 3 studies (18.8%) combining MRI with genomic data; and 1 study (6.2%) combining histologic imaging with clinical data. Studies that compared multimodal models to unimodal-only models demonstrated improved predictive performance. The risk of bias was mixed, most commonly due to inconsistent methodological reporting. Overall, the use of multimodal data in DL assessments of gliomas leads to a more accurate overall survival prediction. However, due to data limitations and a lack of transparency in model and code reporting, the full extent of multimodal DL as a resource for brain tumor patients has not yet been realized.
| S-EPMC9856816 | biostudies-literature