Ontology highlight
ABSTRACT:
SUBMITTER: Hesse J
PROVIDER: S-EPMC8216715 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Hesse Julia J Owenier Christoph C Lautwein Tobias T Zalfen Ria R Weber Jonas F JF Ding Zhaoping Z Alter Christina C Lang Alexander A Grandoch Maria M Gerdes Norbert N Fischer Jens W JW Klau Gunnar W GW Dieterich Christoph C Köhrer Karl K Schrader Jürgen J
eLife 20210621
In the adult heart, the epicardium becomes activated after injury, contributing to cardiac healing by secretion of paracrine factors. Here, we analyzed by single-cell RNA sequencing combined with RNA in situ hybridization and lineage tracing of Wilms tumor protein 1-positive (WT1<sup>+</sup>) cells, the cellular composition, location, and hierarchy of epicardial stromal cells (EpiSC) in comparison to activated myocardial fibroblasts/stromal cells in infarcted mouse hearts. We identified 11 trans ...[more]