Identification of cis-acting determinants mediating the unconventional secretion of tau.

ABSTRACT: The deposition of tau aggregates throughout the brain is a pathological characteristic within a group of neurodegenerative diseases collectively termed tauopathies, which includes Alzheimer's disease. While recent findings suggest the involvement of unconventional secretory pathways driving tau into the extracellular space and mediating the propagation of the disease-associated pathology, many of the mechanistic details governing this process remain elusive. In the current study, we provide an in-depth characterization of the unconventional secretory pathway of tau and identify novel molecular determinants that are required for this process. Here, using Drosophila models of tauopathy, we correlate the hyperphosphorylation and aggregation state of tau with the disease-related neurotoxicity.

SUBMITTER: Katsinelos T 

PROVIDER: S-EPMC8217235 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature