Unknown

Dataset Information

0

A dynamic basal complex modulates mammalian sperm movement.


ABSTRACT: Reproductive success depends on efficient sperm movement driven by axonemal dynein-mediated microtubule sliding. Models predict sliding at the base of the tail - the centriole - but such sliding has never been observed. Centrioles are ancient organelles with a conserved architecture; their rigidity is thought to restrict microtubule sliding. Here, we show that, in mammalian sperm, the atypical distal centriole (DC) and its surrounding atypical pericentriolar matrix form a dynamic basal complex (DBC) that facilitates a cascade of internal sliding deformations, coupling tail beating with asymmetric head kinking. During asymmetric tail beating, the DC's right side and its surroundings slide ~300 nm rostrally relative to the left side. The deformation throughout the DBC is transmitted to the head-tail junction; thus, the head tilts to the left, generating a kinking motion. These findings suggest that the DBC evolved as a dynamic linker coupling sperm head and tail into a single self-coordinated system.

SUBMITTER: Khanal S 

PROVIDER: S-EPMC8217517 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC1304904 | biostudies-literature
| S-EPMC9729212 | biostudies-literature
| S-EPMC1688860 | biostudies-literature
| S-EPMC5473343 | biostudies-literature
| S-EPMC3607503 | biostudies-literature
| S-EPMC8561016 | biostudies-literature
| S-EPMC3804790 | biostudies-literature
| S-EPMC8328089 | biostudies-literature
| S-EPMC5383508 | biostudies-literature
| S-EPMC5327430 | biostudies-literature