Ontology highlight
ABSTRACT:
SUBMITTER: Vikner T
PROVIDER: S-EPMC8217890 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Vikner Tomas T Eklund Anders A Karalija Nina N Malm Jan J Riklund Katrine K Lindenberger Ulman U Bäckman Lars L Nyberg Lars L Wåhlin Anders A
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20210114 7
Microvascular damage in the hippocampus is emerging as a central cause of cognitive decline and dementia in aging. This could be a consequence of age-related decreases in vascular elasticity, exposing hippocampal capillaries to excessive cardiac-related pulsatile flow that disrupts the blood-brain barrier and the neurovascular unit. Previous studies have found altered intracranial hemodynamics in cognitive impairment and dementia, as well as negative associations between pulsatility and hippocam ...[more]