Vaxign2: the second generation of the first Web-based vaccine design program using reverse vaccinology and machine learning.

ABSTRACT: Vaccination is one of the most significant inventions in medicine. Reverse vaccinology (RV) is a state-of-the-art technique to predict vaccine candidates from pathogen's genome(s). To promote vaccine development, we updated Vaxign2, the first web-based vaccine design program using reverse vaccinology with machine learning. Vaxign2 is a comprehensive web server for rational vaccine design, consisting of predictive and computational workflow components. The predictive part includes the original Vaxign filtering-based method and a new machine learning-based method, Vaxign-ML. The benchmarking results using a validation dataset showed that Vaxign-ML had superior prediction performance compared to other RV tools. Besides the prediction component, Vaxign2 implemented various post-prediction anal

SUBMITTER: Ong E 

PROVIDER: S-EPMC8218197 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature