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Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia.

ABSTRACT: Iron deficiency anaemia (IDA) is common in colorectal cancer (CRC), especially, in right-sided CRC which is known to have an overall worse prognosis. The associations between diagnostic pathway (Bowel Cancer Screening Programme (BCSP), IDA, symptomatic) and tumour side/stage was assessed using logistic regression models in 1138 CRC cases presenting during 2010-2016 at a single secondary-care centre in the UK. In the IDA sub-group, the relationship between CRC stage and the event of having a blood count prior to CRC diagnosis was examined using Bayesian parametric survival model. IDA was found as the only significant predictor of right-sided CRC (OR 10.61, 95% CI 7.02-16.52). Early-stage CRC was associated with both the IDA (OR 1.65, 95% CI 1.18-2.29) and BCSP pathway (OR 2.42, 95% CI 1.75-3.37). At any age, the risk of detecting CRC at late-stage was higher in those without a previous blood count check (hazard ratio 1.53, 95% credibility interval 1.08-2.14). The findings of this retrospective observational study suggest a benefit from diagnosing CRC through the detection of IDA, and warrant further research into the prognosis benefit of systematic approach to blood count monitoring of the at-risk population.

SUBMITTER: Almilaji O

PROVIDER: S-EPMC8219720 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia.

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| S-EPMC8249613 | biostudies-literature

Long-term outcomes in patients newly diagnosed with iron deficiency anaemia in general practice: a retrospective cohort study.

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| S-EPMC8092475 | biostudies-literature

Impact of anaemia at discharge following colorectal cancer surgery.

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| S-EPMC7415032 | biostudies-literature

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| S-EPMC8656986 | biostudies-literature

Association between anaemia, iron deficiency anaemia, neglected parasitic infections and socioeconomic factors in rural children of West Malaysia.

Project description:BACKGROUND: Given that micronutrient deficiency, neglected intestinal parasitic infections (IPIs) and poor socioeconomic status are closely linked, we conducted a cross-sectional study to assess the relationship between IPIs and nutritional status of children living in remote and rural areas in West Malaysia. METHODS/FINDINGS: A total of 550 children participated, comprising 520 (94.5%) school children aged 7 to 12 years old, 30 (5.5%) young children aged 1 to 6 years old, 254 (46.2%) boys and 296 (53.8%) girls. Of the 550 children, 26.2% were anaemic, 54.9% iron deficient and 16.9% had iron deficiency anaemia (IDA). The overall prevalence of helminths was 76.5% comprising Trichuris trichiura (71.5%), Ascaris lumbricoides (41.6%) and hookworm infection (13.5%). It was observed that iron deficiency was significantly higher in girls (p?=?0.032) compared to boys. Univariate analysis demonstrated that low level of mother's education (OR?=?2.52; 95% CI?=?1.38-4.60; p?=?0.002), non working parents (OR?=?2.18; 95% CI?=?2.06-2.31; p?=?0.013), low household income (OR?=?2.02; 95% CI?=?1.14-3.59; p?=?0.015), T. trichiura (OR?=?2.15; 95% CI?=?1.21-3.81; p?=?0.008) and A. lumbricoides infections (OR?=?1.63; 95% CI?=?1.04-2.55; p?=?0.032) were significantly associated with the high prevalence of IDA. Multivariate analysis confirmed that low level of mother's education (OR?=?1.48; 95 CI%?=?1.33-2.58; p<0.001) was a significant predictor for IDA in these children. CONCLUSION: It is crucial that a comprehensive primary health care programme for these communities that includes periodic de-worming, nutrition supplement, improved household economy, education, sanitation status and personal hygiene are taken into consideration to improve the nutritional status of these children.

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Role of faecal occult bloods in the diagnosis of iron deficiency anaemia.

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| S-EPMC5369754 | biostudies-other

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