Paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: A case report.

ABSTRACT:

Background

Neuroendocrine carcinomas of the urinary bladder are rare tumors, estimated at less than 1% of urinary bladder malignancies. They are mainly represented by small cell neuroendocrine carcinoma, while large cell neuroendocrine carcinoma (LCNEC) is rarely reported.

Case presentation

We report a case of a 49-year-old man presenting paraplegia caused by a metastatic urinary bladder LCNEC, which was managed with palliative external beam radiotherapy (EBRT) associated with MVAC chemotherapy, including methotrexate, vinblastine sulfate, doxorubicin hydrochloride (Adriamycin), and cisplatin. At the last follow-up of one year after his admission, there was a symptomatic improvement in the pain intensity.

Conclusion

LCNEC of the bladder was first described in 1986, an

SUBMITTER: Tlili G 

PROVIDER: S-EPMC8220165 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature