Gene duplication and subsequent diversification strongly affect phenotypic evolvability and robustness.

ABSTRACT: We study the effects of non-determinism and gene duplication on the structure of genotype-phenotype (GP) maps by introducing a non-deterministic version of the Polyomino self-assembly model. This model has previously been used in a variety of contexts to model the assembly and evolution of protein quaternary structure. Firstly, we show the limit of the current deterministic paradigm which leads to built-in anti-correlation between evolvability and robustness at the genotypic level. We develop a set of metrics to measure structural properties of GP maps in a non-deterministic setting and use them to evaluate the effects of gene duplication and subsequent diversification. Our generalized versions of evolvability and robustness exhibit positive correlation for a subset of genotypes. This posi

SUBMITTER: Jouffrey V 

PROVIDER: S-EPMC8220273 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature