Ontology highlight
ABSTRACT:
SUBMITTER: Thomson J
PROVIDER: S-EPMC8221374 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Thomson Jason J Bewicke-Copley Findlay F Anene Chinedu Anthony CA Gulati Abha A Nagano Ai A Purdie Karin K Inman Gareth J GJ Proby Charlotte M CM Leigh Irene M IM Harwood Catherine A CA Wang Jun J
The Journal of investigative dermatology 20210119 7
Actinic keratoses (AKs) are lesions of epidermal keratinocyte dysplasia and are precursors for invasive cutaneous squamous cell carcinoma (cSCC). Identifying the specific genomic alterations driving the progression from normal skin to skin with AK to skin with invasive cSCC is challenging because of the massive UVR-induced mutational burden characteristic at all stages of this progression. In this study, we report the largest AK whole-exome sequencing study to date and perform a mutational signa ...[more]